hEALTH AND mEDICINE (2): 1) Ontario to fund hip and knee replacements at private clinics; 2)Health Canada approves 1st pill to treat postpartum depression

1) Ontario to fund hip and knee replacements at private clinics

Courtesy Barrie360.com and Canadian Press

By Allison Jones, Dec. 8, 2025.

The next step in Ontario’s plan to expand the number of private clinics offering publicly funded health care will roll out early next year, with four centres offering hip and knee replacements.

Health Minister Sylvia Jones announced today that Ontario is spending $125 million over two years to add up to 20,000 orthopedic surgeries.

Jones says the expansion should ensure that 90 per cent of patients get those procedures within clinically recommended timeframes, up from the current level of 80 per cent.

Ontario has previously expanded the private delivery of public health care services for cataract procedures, as well as MRI and CT scans, and says that has involved 40,000 eye surgeries in the past year and tens of thousands of MRI and CT operating hours.

Critics say the province should instead be putting that money into publicly funded hospitals, which have said they need $1 billion in additional funding.

The four clinics being funded for hip and knee surgeries are OV Surgical Centre in Toronto, Academic Orthopedic Surgical Associates of Ottawa, Windsor Orthopedic Surgical Centre and Schroeder Ambulatory Centre in Richmond Hill.

2)Health Canada approves 1st pill to treat postpartum depression

Courtesy Barrie360.com and Canadian Press

By Nicole Ireland, Dec. 9, 2025.

A pregnant woman stands for a portrait in Dallas on Thursday, May 18, 2023. (AP Photo/LM Otero, File)

Health Canada has approved the first drug designed to treat postpartum depression.

Zuranolone, sold under the brand name Zurzuvae, is a pill taken once a day for 14 days and can start relieving depressive symptoms in as few as three days.

Manufactured by Biogen, the drug has been approved for use in the United States since late 2023 and is also authorized in the U.K. and the European Union.

According to Health Canada’s website, one in five women experience a depression or anxiety disorder during or after pregnancy.

Zuranolone is a welcome drug for women suffering from moderate to severe postpartum depression, said Dr. Crystal Clark, Canada Research Chair in reproductive mental health and a psychiatrist at Women’s College Hospital in Toronto.

Selective serotonin reuptake inhibitor antidepressants are often used to treat postpartum depression, but they generally don’t work as quickly and women have to stay on them for much longer, Clark said.

“Although we have treatment options that can be effective for many who have postpartum depression, this will be the first drug that only needs to be taken for two weeks and has a rapid onset of a few days.”

SSRI antidepressants make the neurotransmitter serotonin more available to areas in the brain associated with mood.

Zuranolone is a synthetic version of allopregnanolone — a metabolite of the hormone progesterone, which fluctuates with pregnancy. The drug acts on gamma-aminobutyric acid receptors in the brain, which are involved in regulating mood.

Hormonal changes have been linked to the onset of postpartum depression symptoms, Clark said.

The medication is recommended for moderate to severe postpartum depression, with severity measured by the level of impairment in daily functioning, Clark said.

Symptoms can include depressed mood or severe mood swings, severe anxiety or panic attacks, intense irritability and anger, feelings of worthlessness, shame or guilt, difficulty bonding with the baby and overwhelming fatigue beyond the sleep deprivation new parents normally face.

Moms with postpartum depression may also have changes in appetite, trouble getting out of bed, or difficulty showering or getting dressed even when she has help with the baby.

In severe cases, they may have thoughts of not wanting to live, Clark said.

Many of her patients with postpartum depression are “shocked that anything is wrong with them.”

“Some of the comments I hear are, ‘I mean, I wanted this pregnancy, I’m excited about the baby, I don’t know why I feel so bad,'” she said.

In an email to The Canadian Press, Health Canada said it has done a “thorough review” of Biogen’s evidence demonstrating “that the drug meets all criteria for safety, effectiveness and quality, and that its benefits outweigh its risks when used as intended.”

Part of that evidence is a clinical trial that used the Hamilton Rating Scale for Depression to measure the change in symptoms in 196 women with severe postpartum depression. They were randomized to take either zuranolone or a placebo pill once a day for 14 days.

There were “significant improvements” in depressive symptoms among those who took the drug, the study said. The primary measurement was taken after the two weeks of treatment, but some women’s symptoms improved as quickly as three days after starting the medication, it said.

The researchers followed up with the study participants after 45 days and found the symptoms remained reduced.

It’s not known how long those effects will last or if there were any recurrences in depressive symptoms beyond that time period, Clark said, but noted that patients in the United States “are doing well” with the drug.

The most common side-effects among study participants who took zuranolone were drowsiness, dizziness, sedation and headache.

Women should not breastfeed while taking the drug until there is more research to determine whether or not it is safe for the baby, Clark said.

Because of the potential drowsiness, she said, it’s a good idea for women to have someone else with them for the first couple of days to help care for the baby until they see how they react to the medication.

Dr. David Silver, a gynecologic psychiatrist at UPMC in Camp Hill, Pa., has been prescribing zuranolone for more than a year and said it’s been a “very important addition” to the postpartum depression treatment arsenal because it acts quickly.

“When you have a woman who is immediately postpartum with a newborn to take care of, time is of the essence,” he said.

Silver said he looks at his patients’ patterns of depression to decide whether the best treatment is an SSRI antidepressant or zuranolone.

“If they’ve had multiple episodes of depression in the past and they had depression that lasted all through their pregnancy … (and) didn’t just start in the third trimester or the postpartum, well, they may just benefit from (an) SSRI then,” he said.

“On the other hand, if somebody comes in and they are not depressed through the pregnancy and then all of a sudden in the third trimester or in the immediate postpartum (they) develop these pronounced symptoms, well, that person to me is the one that I really am thinking about zuranolone for.”

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